Article
ras gene activation in rat tumors induced by benzidine congeners and derived dyes.
Cancer research - 15 Jan 1990
Reynolds S H, Patterson R M, Mennear J H, Maronpot R R, Anderson M W
Abstract excerpt
Dimethoxybenzidine (DMO) and dimethylbenzidine (DM) are used to synthesize dyes such as C.I. Direct Blue 15 and C.I. Acid Red 114, respectively. These commercially used dyes are metabolically degraded to DMO or DM in the intestinal tract of rodents and subsequently DMO and DM are absorbed into th...
Topics
- Animals
- Benzidines
- Coloring Agents
- DNA, Neoplasm
- Dianisidine
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Mutation
- Neoplasms, Experimental
- Nucleic Acid Hybridization
- Proto-Oncogenes