Article
The role of non-ras transforming genes in chemical carcinogenesis.
Environmental health perspectives - 1 Jun 1991
Cooper C S
Abstract excerpt
DNA transfection experiments using the NIH 3T3 mouse fibroblast cell line have demonstrated that chemically induced tumors and chemically transformed cell lines frequently contain dominant transforming genes. Although many of the genes detected using the NIH 3T3 transfection-transformation assay are activated versions of H-ras, K-ras, and N-ras, in some experimental systems activated forms of genes such as met...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Carcinogens
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cocarcinogenesis
- DNA
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Gene Rearrangement