Article
Mutational activation of the cellular Harvey ras oncogene in rat esophageal papillomas induced by methylbenzylnitrosamine.
Cancer research - 1 Mar 1990
Wang Y, You M, Reynolds S H, Stoner G D, Anderson M W
Abstract excerpt
Epidemiological studies have demonstrated a strong association between human esophageal cancer and exposure to N-nitroso carcinogens. Esophageal tumors can be induced in experimental animals, especially in rats, by many N-nitroso carcinogens. In the present study, rat esophageal tumors induced by...
Topics
- Animals
- Base Sequence
- Carcinogens
- Cell Transformation, Neoplastic
- DNA, Neoplasm
- Dimethylnitrosamine
- Esophageal Neoplasms
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Rats
- Rats, Inbred F344
- Transfection
