Ki-ras mutations in spontaneous and chemically induced renal tumors of the rat.

doi:10.1002/mc.2940040608

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Article

Ki-ras mutations in spontaneous and chemically induced renal tumors of the rat.

Molecular carcinogenesis - 1 Jan 1991

Ohgaki H, Kleihues P, Hard G C

Abstract excerpt

A high frequency of point mutations at codon 12 of the Ki-ras gene has previously been reported for rat kidney mesenchymal tumors induced by methylating N-nitroso compounds. In this study, we analyzed renal tumors with divergent histogenesis, i.e., mesenchymal tumors (sarcomas), cortical epitheli...

Topics

Animals
Base Sequence
Carcinogens
Genes, ras
Kidney Neoplasms
Molecular Sequence Data
Mutation
Neoplasms, Experimental
Oligonucleotides
Polymerase Chain Reaction
Proto-Oncogene Proteins p21(ras)
Rats

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