Article
Ki-ras mutations in spontaneous and chemically induced renal tumors of the rat.
Molecular carcinogenesis - 1 Jan 1991
Ohgaki H, Kleihues P, Hard G C
Abstract excerpt
A high frequency of point mutations at codon 12 of the Ki-ras gene has previously been reported for rat kidney mesenchymal tumors induced by methylating N-nitroso compounds. In this study, we analyzed renal tumors with divergent histogenesis, i.e., mesenchymal tumors (sarcomas), cortical epithelial tumors (carcinomas), and embryonal tumors (nephroblastomas). Renal mesenchymal tumors and carcinomas were induced in...
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