MNU-induced point mutation and activation of c-Ha-ras oncogene in cell lines derived from human pancreas explants.

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Article

MNU-induced point mutation and activation of c-Ha-ras oncogene in cell lines derived from human pancreas explants.

Biochemistry international - 1 Jan 1990

Maheshwari K K, Parsa I, Marsh W H

Abstract excerpt

Point mutation and activation of c-Ha-ras oncogene was studied at various stages of carcinogenesis in cell lines developed from MNU-treated human pancreas explants. DNAs from normal pancreas and nontumorigenic cell lines showed no transforming activity in NIH 3T3 cells whereas DNA from one of the...

Topics

Blotting, Southern
Cell Line
Cell Transformation, Neoplastic
DNA
DNA, Neoplasm
Gene Amplification
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Mutation
Pancreas
Restriction Mapping
Transcription, Genetic
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 2183801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2183801-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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