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Article

Islet-infiltrating T cell clones from non-obese diabetic mice that promote or prevent accelerated onset diabetes.

European journal of immunology - 1 Apr 1991

Pankewycz O, Strom T B, Rubin-Kelley V E

Abstract excerpt

In humans and non-obese diabetic mice (NOD), insulin-dependent diabetes mellitus (IDDM) results from a spontaneous T cell-dependent autoimmune destruction of the insulin-producing pancreatic beta cells. Previous data suggest that a delicate balance between autoaggressive T cells and suppressor-type immune phenomena determine whether expression of autoimmunity is limited to insulitis or progresses to IDDM. To...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
Autoimmune Diseases
CD4 Antigens
CD8 Antigens
Cell Line
Cytotoxicity, Immunologic
Diabetes Mellitus, Type 1
Female
Islets of Langerhans
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred Strains

Phenotype

T-Lymphocytes

Source

Identifiers

PMID: 1902177
DOI: 10.1002/eji.1830210403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1902177-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Islet-infiltrating T cell clones from non-obese diabetic mice that promote or prevent accelerated onset diabetes.PMID 1902177Read ↗

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