Article
beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2009
Li Li, He Qiuming, Garland Alaina, Yi Zuoan, Aybar Lydia T, Kepler Thomas B, Frelinger Jeffrey A, Wang Bo, Tisch Roland
Abstract excerpt
Type 1 diabetes is an autoimmune disease mediated by beta cell-specific CD4(+) and CD8(+) T cells. Tracking beta cell-specific T cells is one approach to monitor the diabetogenic response in at risk or diabetic individuals. Such analyses, however, are limited to PBL because T cells infiltrating the pancreatic islets are normally inaccessible. A key issue is whether peripheral beta cell-specific T cells accurately...
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