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Article

Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.

The Journal of clinical investigation - 1 Apr 1999

Amrani A, Verdaguer J, Anderson B, Utsugi T, Bou S, Santamaria P

Abstract excerpt

Autoimmune diabetes in nonobese diabetic (NOD) mice results from destruction of pancreatic beta cells by T lymphocytes. It is believed that CD8(+) cytotoxic T lymphocytes (CTLs) effect the initial beta-cell insult in diabetes, but the mechanisms remain unclear. Studies of NOD.lpr mice have suggested that disease initiation is a Fas-dependent process, yet perforin-deficient NOD mice rarely develop diabetes despite...

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Identifiers

PMID: 10207172
DOI: 10.1172/JCI6266
PMCID: PMC408282

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.PMID 10207172Read ↗

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