Article
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.
Nature - 12 May 2005
Kent Sally C, Chen Yahua, Bregoli Lisa, Clemmings Sue M, Kenyon Norma Sue, Ricordi Camillo, Hering Bernhard J, Hafler David A
Abstract excerpt
In autoimmune type 1 diabetes, pathogenic T lymphocytes are associated with the specific destruction of insulin-producing beta-islet cells. Identification of the autoantigens involved in triggering this process is a central question. Here we examined T cells from pancreatic draining lymph nodes, the site of islet-cell-specific self-antigen presentation. We cloned single T cells in a non-biased manner from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.