Article
Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a β-cell neo-self-antigen in type 1 diabetes prone NOD mice.
European journal of immunology - 1 Dec 2010
Cox Selwyn Lewis, Stolp Jessica, Hallahan Nicole L, Counotte Jacqueline, Zhang Wenyu, Serreze David V, Basten Antony, Silveira Pablo A
Abstract excerpt
Self-reactive B lymphocytes contribute to type 1 diabetes pathogenesis as APC and auto-Ab producers in NOD mice and humans. To shed light on the mechanisms responsible for the breakdown in B-lymphocyte self-tolerance to β-cell Ag, we utilised a model whereby hen-egg lysozyme (HEL)-specific Ig Tg (IgHEL-Tg)-Tg B lymphocytes were allowed to develop in or were transferred into mice expressing the HEL Tg under an...
Topics
- Adoptive Transfer
- Animals
- Autoantigens
- B-Lymphocytes
- Cytokines
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Immunoglobulins
- Insulin
- Insulin-Secreting Cells
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD