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Article

Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a β-cell neo-self-antigen in type 1 diabetes prone NOD mice.

European journal of immunology - 1 Dec 2010

Cox Selwyn Lewis, Stolp Jessica, Hallahan Nicole L, Counotte Jacqueline, Zhang Wenyu, Serreze David V, Basten Antony, Silveira Pablo A

Abstract excerpt

Self-reactive B lymphocytes contribute to type 1 diabetes pathogenesis as APC and auto-Ab producers in NOD mice and humans. To shed light on the mechanisms responsible for the breakdown in B-lymphocyte self-tolerance to β-cell Ag, we utilised a model whereby hen-egg lysozyme (HEL)-specific Ig Tg (IgHEL-Tg)-Tg B lymphocytes were allowed to develop in or were transferred into mice expressing the HEL Tg under an...

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PMID: 21108464
DOI: 10.1002/eji.201040817

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