Article
Islet abnormalities in the pathogenesis of autoimmune diabetes.
Trends in endocrinology and metabolism: TEM - 1 Jul 2002
Rosmalen Judith G M, Leenen Pieter J M, Pelegri Carme, Drexhage Hemmo A, Homo-Delarche Françoise
Abstract excerpt
Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease that results in the destruction of the insulin-producing beta cells in the pancreatic islets of Langerhans. In spite of extensive genetic and immunological studies, mainly performed in the non-obese diabetic (NOD) spontaneous mouse model, the etiology of the autoimmune attack remains unknown. Several autoantigens have been identified and numerous...
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