Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2012

Antal Zoltan, Baker Jason C, Smith Carla, Jarchum Irene, Babad Jeffrey, Mukherjee Gayatri, Yang Yang, Sidney John, Sette Alessandro, Santamaria Pere, DiLorenzo Teresa P

Abstract excerpt

Type 1 diabetes is an autoimmune disease characterized by T cell responses to β cell Ags, including insulin. Investigations employing the NOD mouse model of the disease have revealed an essential role for β cell-specific CD8(+) T cells in the pathogenic process. As CD8(+) T cells specific for β cell Ags are also present in patients, these reactivities have the potential to serve as therapeutic targets or markers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to C-Peptide
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Epitopes, T-Lymphocyte

Share to HLA-A11 Antigen

Share to HLA-A2 Antigen

Share to Mice, Inbred NOD

Share to Mice, Transgenic

Source

Open in PubMed Open full text

Identifiers

PMID: 22539795
DOI: 10.4049/jimmunol.1102930
PMCID: PMC3358524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes.PMID 22539795Read ↗

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.Semantic proximity Read ↗

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression.Semantic proximity Read ↗

Type 1 diabetes: lessons for other autoimmune diseases?Semantic proximity Read ↗

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression <sup>1</sup>Semantic proximity Read ↗

A comprehensive guide to antibody and T‐cell responses in type 1 diabetesSemantic proximity Read ↗

An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.Semantic proximity Read ↗

Understanding autoimmune diabetes: insights from mouse models.Semantic proximity Read ↗

HLA class I epitope discovery in type 1 diabetes.Semantic proximity Read ↗

Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.Semantic proximity Read ↗

An update on the use of NOD mice to study autoimmune (Type 1) diabetes.Semantic proximity Read ↗

Autoimmune diabetes: the role of T cells, MHC molecules and autoantigens.Semantic proximity Read ↗

Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.