Article
Enhanced expression of p53 in human cells infected with mutant adenoviruses.
Virology - 1 Sept 1994
Grand R J, Grant M L, Gallimore P H
Abstract excerpt
The expression of p53 in human cells infected with wild-type (wt) and mutant adenoviruses has been examined. With wt Ad5 and Ad12, and Ad12 viruses carrying lesions in the E1A or the 19K E1B genes, there was a pronounced decrease in level of p53 during the course of infection. However, when cells were infected with mutant viruses which did not express the larger E1B proteins (Ad12 dl620 and in602 and Ad5 dl338...
Topics
- Adenoviridae
- Adenovirus E1B Proteins
- Adenovirus E4 Proteins
- Cell Line
- Cell Line, Transformed
- Cell Transformation, Viral
- Humans
- Mutation
- Tumor Suppressor Protein p53