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Article

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection.

Journal of virology - 1 Dec 1998

Goodrum F D, Ornelles D A

Abstract excerpt

The ability of the adenovirus type 5 E1B 55-kDa mutants dl1520 and dl338 to replicate efficiently and independently of the cell cycle, to synthesis viral DNA, and to lyse infected cells did not correlate with the status of p53 in seven cell lines examined. Rather, cell cycle-independent replication and virus-induced cell killing correlated with permissivity to viral replication. This correlation extended to...

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Identifiers

PMID: 9811681
DOI: 10.1128/JVI.72.12.9479-9490.1998
PMCID: PMC110444

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