p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection.

doi:10.1128/JVI.72.12.9479-9490.1998

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Article

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection.

Journal of virology - 1 Dec 1998

Goodrum F D, Ornelles D A

Abstract excerpt

The ability of the adenovirus type 5 E1B 55-kDa mutants dl1520 and dl338 to replicate efficiently and independently of the cell cycle, to synthesis viral DNA, and to lyse infected cells did not correlate with the status of p53 in seven cell lines examined. Rather, cell cycle-independent replicati...

Topics

Adenovirus E1B Proteins
Adenoviruses, Human
Cell Cycle
Cell Death
Cell Line
DNA, Viral
Gene Expression Regulation, Viral
Genes, Viral
HeLa Cells
Humans
Mutation
Phenotype
Temperature
Tumor Suppressor Protein p53
Virulence
Virus Replication

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