Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.

doi:10.1038/357082a0

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Article

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.

Nature - 7 May 1992

Yew P R, Berk A J

Abstract excerpt

The cellular phosphoprotein p53 inhibits progression through the mammalian cell cycle. Both p53 alleles are frequently mutated in human tumours, indicating that p53 is a tumour suppressor. Recent studies have suggested that p53 functions as a transcriptional activator, but the significance of thi...

Topics

Adenovirus Early Proteins
Animals
Cell Transformation, Viral
Cells, Cultured
Gene Expression
Mutation
Oncogene Proteins, Viral
Protein Binding
Rats
Structure-Activity Relationship
Transcriptional Activation
Tumor Suppressor Protein p53

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