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Article

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.

Nature - 7 May 1992

Yew P R, Berk A J

Abstract excerpt

The cellular phosphoprotein p53 inhibits progression through the mammalian cell cycle. Both p53 alleles are frequently mutated in human tumours, indicating that p53 is a tumour suppressor. Recent studies have suggested that p53 functions as a transcriptional activator, but the significance of this activity in cell-cycle control has not been established. The adenovirus 2 (Ad2) early 1B (E1B) 55K protein binds to...

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Identifiers

PMID: 1533443
DOI: 10.1038/357082a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.PMID 1533443Read ↗

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Association between the cellular p53 and the adenovirus 5 E1B-55kd proteins reduces the oncogenicity of Ad-transformed cells.Semantic proximity Read ↗

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.Semantic proximity Read ↗

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