Article
A p53 mutation in exon 5 associated with adenovirus transformation.
Molecular carcinogenesis - 1 Jan 1995
Eyler Y L, Siwarski D F, Huppi K E, Lewis A M
Abstract excerpt
The adenovirus type 5 (Ad5) 55-kDa E1B oncoprotein has been shown to form complexes with the p53 tumor suppressor protein. These complexes are thought to interfere with normal p53 activity and may be responsible for the paucity of p53 mutations in cells transformed by these viruses. This report d...
Topics
- Adenovirus E1B Proteins
- Animals
- Base Sequence
- Blotting, Northern
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Exons
- Genes, p53
- Mastadenovirus
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Precipitin Tests