Transactivation of the p53 oncogene by E1a gene products.

doi:10.1016/0042-6822(90)90525-v

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Article

Transactivation of the p53 oncogene by E1a gene products.

Virology - 1 Aug 1990

Braithwaite A, Nelson C, Skulimowski A, McGovern J, Pigott D, Jenkins J

Abstract excerpt

Infection of quiescent rat kidney cells with human adenovirus is shown to transcriptionally stimulate (transactivate) the p53 oncogene. The increased transcription results in an accumulation of p53-specific mRNA in parallel with an increase in p53 protein levels, although there is a considerable delay between transcriptional activation and the detection of stable p53 mRNA and protein. The induction of p53 is...

Topics

Adenovirus Early Proteins
Adenoviruses, Human
Animals
Blotting, Western
Cell Line
DNA Replication
DNA-Binding Proteins
Interphase
Mutation
Oncogene Proteins
Oncogene Proteins, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogenes

Phosphoproteins

RNA, Messenger

Rats

Transcription, Genetic

Transcriptional Activation

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 2142558
DOI: 10.1016/0042-6822(90)90525-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2142558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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