Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.

doi:10.1128/JVI.72.11.8510-8516.1998

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Article

Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.

Journal of virology - 1 Nov 1998

Roth J, König C, Wienzek S, Weigel S, Ristea S, Dobbelstein M

Abstract excerpt

The adenovirus E1B 55-kDa and E4 34-kDa oncoproteins bind and inactivate the p53 tumor suppressor gene product, resulting in cell transformation. A recently discovered cellular protein, p73, shows extensive similarities to p53 in structure and function. Here we show that the simultaneous transien...

Topics

Adenovirus E1B Proteins
Adenovirus E4 Proteins
Adenoviruses, Human
Amino Acid Sequence
Base Sequence
Cell Line
DNA Primers
DNA-Binding Proteins
Genes, Tumor Suppressor
Genes, p53
Humans
Macromolecular Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Weight

Mutation

Nuclear Proteins

Transcriptional Activation

Transfection

Tumor Protein p73

Source

Open in PubMed Open full text

Identifiers

PMID: 9765388
DOI: 10.1128/JVI.72.11.8510-8516.1998
PMCID: PMC110260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9765388-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.PMID 9765388Read ↗

Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73Semantic proximity Read ↗

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection.Semantic proximity Read ↗

Comparative Analysis of P73 and P53 Regulation and Effector FunctionsSemantic proximity Read ↗

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.Semantic proximity Read ↗

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.Semantic proximity Read ↗

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53Semantic proximity Read ↗

Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.Semantic proximity Read ↗

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.Semantic proximity Read ↗

The cellular oncogene p53 can be activated by mutagenesis.Semantic proximity Read ↗

A p53 mutation in exon 5 associated with adenovirus transformation.Semantic proximity Read ↗

Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73.Semantic proximity Read ↗

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.Semantic proximity Read ↗

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