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Article

Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.

Journal of virology - 1 Nov 1998

Roth J, König C, Wienzek S, Weigel S, Ristea S, Dobbelstein M

Abstract excerpt

The adenovirus E1B 55-kDa and E4 34-kDa oncoproteins bind and inactivate the p53 tumor suppressor gene product, resulting in cell transformation. A recently discovered cellular protein, p73, shows extensive similarities to p53 in structure and function. Here we show that the simultaneous transient expression of E1B 55-kDa and E4 34-kDa proteins is sufficient to drastically shorten the intracellular half-life of...

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Identifiers

PMID: 9765388
DOI: 10.1128/JVI.72.11.8510-8516.1998
PMCID: PMC110260

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.PMID 9765388Read ↗

Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73Semantic proximity Read ↗

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection.Semantic proximity Read ↗

Comparative Analysis of P73 and P53 Regulation and Effector FunctionsSemantic proximity Read ↗

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.Semantic proximity Read ↗

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.Semantic proximity Read ↗

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53Semantic proximity Read ↗

Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.Semantic proximity Read ↗

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.Semantic proximity Read ↗

The cellular oncogene p53 can be activated by mutagenesis.Semantic proximity Read ↗

A p53 mutation in exon 5 associated with adenovirus transformation.Semantic proximity Read ↗

Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73.Semantic proximity Read ↗

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.Semantic proximity Read ↗

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