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Article

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection.

Journal of virology - 1 Jul 2004

Hobom Urs, Dobbelstein Matthias

Abstract excerpt

The adenovirus E1B-55-kDa protein binds and inactivates the tumor suppressor protein p53. However, the role of this interaction during infection is still poorly understood and was therefore examined here. Infection with a virus carrying the E1B-55-kDa mutation R239A, preventing the interaction with p53, led to the accumulation of p53. However, p53 target genes were not activated in the infected cells, although...

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Identifiers

PMID: 15220443
DOI: 10.1128/JVI.78.14.7685-7697.2004
PMCID: PMC434109

Genes

TRRAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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