Article
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells.
Science (New York, N.Y.) - 18 Oct 1996
Bischoff J R, Kirn D H, Williams A, Heise C, Horn S, Muna M, Ng L, Nye J A, Sampson-Johannes A, Fattaey A, McCormick F
Abstract excerpt
The human adenovirus E1B gene encodes a 55-kilodalton protein that inactivates the cellular tumor suppressor protein p53. Here it is shown that a mutant adenovirus that does not express this viral protein can replicate in and lyse p53-deficient human tumor cells but not cells with functional p53....
Topics
- Adenovirus E1B Proteins
- Adenoviruses, Human
- Animals
- Cytopathogenic Effect, Viral
- Gene Deletion
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Neoplasms, Experimental
- Sigmodontinae
- Transplantation, Heterologous