Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants.

doi:10.1128/jvi.77.21.11588-11595.2003

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Article

Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants.

Journal of virology - 1 Nov 2003

Hann Byron, Balmain Allan

Abstract excerpt

ONYX-015 (dl1520) is an E1B 55-kilodalton protein-deficient replicating adenovirus that is currently in clinical trials as an antitumor agent. On the basis of the observation that the E1B 55kD gene product is able to bind to and inactivate p53, ONYX-015's mechanism of action is proposed to involve selective replication in and killing of p53-deficient cells. While its efficacy as a therapeutic agent appears...

Topics

Adenoviridae
Adenovirus E1B Proteins
Adenoviruses, Human
Bronchi
Cells, Cultured
Epithelial Cells
Gene Expression Regulation, Viral
Humans
Mutation
Tumor Suppressor Protein p53
Viral Vaccines
Virus Replication

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Identifiers

PMID: 14557644
DOI: 10.1128/jvi.77.21.11588-11595.2003
PMCID: PMC229311

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