Article
Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.
Journal of virology - 1 Dec 1998
Rothmann T, Hengstermann A, Whitaker N J, Scheffner M, zur Hausen H
Abstract excerpt
The 55-kDa E1B protein of adenovirus, which binds to and inactivates the tumor suppressor protein p53, is not expressed in the adenoviral mutant termed ONYX-015 (i.e., dl1520). It was reported that the mutant virus due to a deletion in E1B is able to replicate only in cells deficient for wild-typ...
Topics
- Adenoviruses, Human
- Cells, Cultured
- Cytopathogenic Effect, Viral
- Defective Viruses
- Gene Expression
- Genetic Therapy
- Genetic Vectors
- Humans
- Mutation
- Neoplasms
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53
- Virus Replication