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Article

Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.

Journal of virology - 1 Dec 1998

Rothmann T, Hengstermann A, Whitaker N J, Scheffner M, zur Hausen H

Abstract excerpt

The 55-kDa E1B protein of adenovirus, which binds to and inactivates the tumor suppressor protein p53, is not expressed in the adenoviral mutant termed ONYX-015 (i.e., dl1520). It was reported that the mutant virus due to a deletion in E1B is able to replicate only in cells deficient for wild-type p53. Accordingly, dl1520 is currently being evaluated as a potential tool in the therapy of p53 deficient cancers. In...

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Identifiers

PMID: 9811680
DOI: 10.1128/JVI.72.12.9470-9478.1998
PMCID: PMC110441

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Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.PMID 9811680Read ↗

In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy.Semantic proximity Read ↗

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).Semantic proximity Read ↗

Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants.Semantic proximity Read ↗

Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway?Semantic proximity Read ↗

Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity.Semantic proximity Read ↗

Evidence that Replication of the Antitumor Adenovirus ONYX-015 Is Not Controlled by the p53 and p14 ARF Tumor Suppressor GenesSemantic proximity Read ↗

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection.Semantic proximity Read ↗

The cytotoxic effect of E1B 55-kDa mutant adenovirus on human hepatocellular carcinoma cell lines.Semantic proximity Read ↗

Phase I Trial of Intraperitoneal Injection of the E1B-55-kd-Gene-Deleted Adenovirus ONYX-015 (dl1520) Given on Days 1 Through 5 Every 3 Weeks in Patients With Recurrent/Refractory Epithelial Ovarian CancerSemantic proximity Read ↗

Efficient induction of cell death by adenoviruses requires binding of E1B55k and p53.Semantic proximity Read ↗

Clinical utility of recombinant adenoviral human p53 gene therapy: current perspectivesSemantic proximity Read ↗

Assessment of growth inhibition and morphological changes in in vitro and in vivo hepatocellular carcinoma models post treatment with dl1520 adenovirus.Semantic proximity Read ↗

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