Stabilization of p53 by adenovirus E1A occurs through its amino-terminal region by modification of the ubiquitin-proteasome pathway.

doi:10.1074/jbc.273.32.20036

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Article

Stabilization of p53 by adenovirus E1A occurs through its amino-terminal region by modification of the ubiquitin-proteasome pathway.

The Journal of biological chemistry - 7 Aug 1998

Nakajima T, Morita K, Tsunoda H, Imajoh-Ohmi S, Tanaka H, Yasuda H, Oda K

Abstract excerpt

The human epidermoid carcinoma-derived cell line MA1, established by introduction of the adenovirus E1A 12 S cDNA linked to the hormone-inducible promoter, elicits apoptosis after induction of E1A12 S in response to dexamethasone. E1A expression caused accumulation of wild type p53 more than 10-f...

Topics

Adenovirus E1A Proteins
Apoptosis
Calcium
Carcinoma, Squamous Cell
Conserved Sequence
Cysteine Endopeptidases
Dexamethasone
Gene Expression Regulation, Neoplastic
Humans
Multienzyme Complexes
Mutation
Nuclear Proteins
Proteasome Endopeptidase Complex
Proto-Oncogene Proteins

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Identifiers

PMID: 9685342
DOI: 10.1074/jbc.273.32.20036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9685342-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-mdm2

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Ubiquitins