Article
The BM12 mutation and autoantibodies to dsDNA in NZB.H-2bm12 mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1990
Chiang B L, Bearer E, Ansari A, Dorshkind K, Gershwin M E
Abstract excerpt
Molecular and genetic tools have been used to shed light on the genes that contribute to susceptibility to murine lupus and the mechanisms that lead to immunopathology. The MHC genes and their products have been consistently shown to contribute toward the development of disease. To understand the...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Antinuclear
- Autoimmune Diseases
- Bone Marrow
- Bone Marrow Cells
- DNA
- DNA, Single-Stranded
- Flow Cytometry
- Genotype
- H-2 Antigens
- Histocompatibility Antigens Class II
- Immunoglobulin G
- Mice
- Mice, Mutant Strains
- Proteinuria
- Spleen