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Article

Lessons from BXSB and related mouse models.

International reviews of immunology - 1 Jan 2000

Izui S, Ibnou-Zekri N, Fossati-Jimack L, Iwamoto M

Abstract excerpt

The BXSB murine strain spontaneously develops an autoimmune syndrome with features of systemic lupus erythematosus (SLE) that affects males much earlier than females, due to the presence of an as yet unidentified mutant gene located on its Y chromosome, designated Yaa (Y-linked autoimmune acceleration). The Yaa gene by itself is unable to induce significant autoimmune responses in mice without an apparent SLE...

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PMID: 11016427
DOI: 10.3109/08830180009055507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lessons from BXSB and related mouse models.PMID 11016427Read ↗

The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells.Semantic proximity Read ↗

Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation.Semantic proximity Read ↗

Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.Semantic proximity Read ↗

Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease.Semantic proximity Read ↗

Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.Semantic proximity Read ↗

The autoimmune accelerating yaa mutation does not accelerate murine AIDS.Semantic proximity Read ↗

Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice.Semantic proximity Read ↗

Genetic complementation in female (BXSB x NZW)F2 mice.Semantic proximity Read ↗

Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus.Semantic proximity Read ↗

BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa.Semantic proximity Read ↗

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Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus.Semantic proximity Read ↗

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