Article
Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.
European journal of immunology - 1 Mar 2013
Kawano Shinya, Lin Qingshun, Amano Hirofumi, Kaneko Toshiyuki, Nishikawa Keiko, Tsurui Hiromichi, Tada Norihiro, Nishimura Hiroyuki, Takai Toshiyuki, Shirai Toshikazu, Takasaki Yoshinari, Hirose Sachiko
Abstract excerpt
We previously established an IgG Fc receptor IIB (FcγRIIB)-deficient C57BL/6 (B6)-congenic mouse strain (KO1), which spontaneously develops rheumatoid arthritis (RA), but not systemic lupus erythematosus (SLE). Here, we show that when Y chromosome-linked autoimmune acceleration (Yaa) mutation was introduced in KO1 strain (KO1.Yaa), the majority of KO1.Yaa mice did not develop RA, but instead did develop SLE. This...
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