Mutations that abolish the ability of Ha-Ras to associate with Raf-1.

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Article

Mutations that abolish the ability of Ha-Ras to associate with Raf-1.

Oncogene - 1 Aug 1994

Shirouzu M, Koide H, Fujita-Yoshigaki J, Oshio H, Toyama Y, Yamasaki K, Fuhrman S A, Villafranca E, Kaziro Y, Yokoyama S

Abstract excerpt

Recent studies have revealed that Ras can associate physically with Raf. In the present study, we tested 34 mutants of Ha-Ras carrying substitution(s) in the region of residues 23-71 for their ability to associate with Raf-1. Mouse Ba/F3 cell lysates were incubated with each mutant Ras protein, i...

Topics

Animals
Cells, Cultured
Genes, ras
Guanosine Diphosphate
Guanosine Triphosphate
Mice
Mutation
PC12 Cells
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf
Rats

Source

Open in PubMed

Identifiers

PMID: 8036000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8036000-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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