Article
Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C.
Science (New York, N.Y.) - 3 Apr 1998
Marais R, Light Y, Mason C, Paterson H, Olson M F, Marshall C J
Abstract excerpt
Receptor tyrosine kinase-mediated activation of the Raf-1 protein kinase is coupled to the small guanosine triphosphate (GTP)-binding protein Ras. By contrast, protein kinase C (PKC)-mediated activation of Raf-1 is thought to be Ras independent. Nevertheless, stimulation of PKC in COS cells led t...
Topics
- Animals
- COS Cells
- Calcium-Calmodulin-Dependent Protein Kinases
- Chlorocebus aethiops
- Enzyme Activation
- Enzyme Inhibitors
- Epidermal Growth Factor
- Guanosine Triphosphate
- Indoles
- Mutation
- Protein Kinase C
- Proto-Oncogene Proteins c-raf
- Receptor, Muscarinic M1
- Receptors, Muscarinic
- Signal Transduction
- Tetradecanoylphorbol Acetate
- ras Proteins