Membrane recruitment of Raf-1 is not the only function of Ras in Raf-1 activation.

doi:10.1038/sj.onc.1201582

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Article

Membrane recruitment of Raf-1 is not the only function of Ras in Raf-1 activation.

Oncogene - 11 Dec 1997

Tamada M, Hu C D, Kariya K, Okada T, Kataoka T

Abstract excerpt

Ras interacts with Raf-1 and stimulates its kinase activity, which results in activation of the mitogen-activated protein (MAP) kinase cascade. It has been proposed that the main function of Ras in Raf-1 activation is to recruit Raf-1 to the plasma membrane, where a separate activation event such...

Topics

Animals
Biological Transport
COS Cells
Calcium-Calmodulin-Dependent Protein Kinases
Cell Membrane
Humans
Membrane Proteins
Mitogen-Activated Protein Kinase 1
Mutation
Oncogene Protein p21(ras)
Proto-Oncogene Proteins c-raf
Signal Transduction
ras Proteins

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