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Article

Membrane recruitment of Raf-1 is not the only function of Ras in Raf-1 activation.

Oncogene - 11 Dec 1997

Tamada M, Hu C D, Kariya K, Okada T, Kataoka T

Abstract excerpt

Ras interacts with Raf-1 and stimulates its kinase activity, which results in activation of the mitogen-activated protein (MAP) kinase cascade. It has been proposed that the main function of Ras in Raf-1 activation is to recruit Raf-1 to the plasma membrane, where a separate activation event such as phosphorylation takes place. Here, we examined the activities of various mutants of human Ha-Ras to induce membrane...

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Identifiers

PMID: 9416839
DOI: 10.1038/sj.onc.1201582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Membrane recruitment of Raf-1 is not the only function of Ras in Raf-1 activation.PMID 9416839Read ↗

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