Article
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase.
The Journal of biological chemistry - 11 Sept 1998
Yan J, Roy S, Apolloni A, Lane A, Hancock J F
Abstract excerpt
Ha-, N-, and Ki-Ras are ubiquitously expressed in mammalian cells and can all interact with the same set of effector proteins. We show here, however, that in vivo there are marked quantitative differences in the ability of Ki- and Ha-Ras to activate Raf-1 and phosphoinositide 3-kinase. Thus, Ki-R...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Cell Membrane
- Enzyme Activation
- Genetic Variation
- Humans
- Kinetics
- Molecular Sequence Data
- Phosphatidylinositol 3-Kinases
- Proto-Oncogene Proteins c-raf
- Proto-Oncogene Proteins p21(ras)
- Recombinant Proteins
- Sequence Alignment
- Sequence Homology, Amino Acid
- Transfection