Article
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992
Robbins D J, Cheng M, Zhen E, Vanderbilt C A, Feig L A, Cobb M H
Abstract excerpt
The small GTP-binding protein Ras appears to be required for transformation and differentiation induced by tyrosine kinases. The Ras requirement may be limited to a few tyrosine kinase-regulated signaling pathways or may be universal for all tyrosine kinase actions. Because both Ras and the microtubule-associated protein 2 kinases ERK1 and ERK2 have been implicated in events that lead to neurite outgrowth, we...
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