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Article

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.

Nature - 22 Jul 1993

Warne P H, Viciana P R, Downward J

Abstract excerpt

The Ras proteins are key regulators of the growth of eukaryotic cells, but their direct target enzymes, or 'effectors', are unknown. The protein encoded by the c-raf-1 proto-oncogene is thought to function downstream of p21ras because disruption of Raf blocks signalling by Ras in a number of systems. Here we report that the amino-terminal cysteine-rich regulatory region of p74c-raf-1 expressed as a...

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PMID: 8332195
DOI: 10.1038/364352a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.PMID 8332195Read ↗

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.Semantic proximity Read ↗

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Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro.Semantic proximity Read ↗

Improved binding of raf to Ras.GDP is correlated with biological activity.Semantic proximity Read ↗

Mutations that abolish the ability of Ha-Ras to associate with Raf-1.Semantic proximity Read ↗

The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype.Semantic proximity Read ↗

A multiple-approach scintillation proximity assay to measure the association between Ras and Raf.Semantic proximity Read ↗

Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C.Semantic proximity Read ↗

A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition.Semantic proximity Read ↗

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