Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.

doi:10.1038/364352a0

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Article

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.

Nature - 22 Jul 1993

Warne P H, Viciana P R, Downward J

Abstract excerpt

The Ras proteins are key regulators of the growth of eukaryotic cells, but their direct target enzymes, or 'effectors', are unknown. The protein encoded by the c-raf-1 proto-oncogene is thought to function downstream of p21ras because disruption of Raf blocks signalling by Ras in a number of syst...

Topics

Glutathione Transferase
Guanosine Triphosphate
Mutation
Peptide Fragments
Protein Binding
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf
Proto-Oncogene Proteins p21(ras)
Recombinant Fusion Proteins
Signal Transduction
Zinc

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