The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype.

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Article

The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype.

The Journal of biological chemistry - 2 Dec 1994

Fridman M, Tikoo A, Varga M, Murphy A, Nur-E-Kamal M S, Maruta H

Abstract excerpt

v-Ha-Ras, an oncogenic Ras mutant, causes malignant transformation of mammalian cells by recruiting c-Raf-1, a cytosolic Ser/Thr kinase, to the plasma membranes/cytoskeleton. The kinase activity of c-Raf-1 resides in the C-terminal half, which activates mitogen-activated protein (MAP) kinase kina...

Topics

3T3 Cells
Animals
Base Sequence
Cell Division
Cell Transformation, Neoplastic
Humans
Kinetics
Mammals
Mice
Molecular Sequence Data
Neurofibromin 1
Oncogene Protein p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Fragments

Phenotype

Point Mutation

Protein Biosynthesis

Protein Serine-Threonine Kinases

Protein Structure, Secondary

Source

Open in PubMed

Identifiers

PMID: 7982912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7982912-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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