Article
The occurrence and significance of V gene mutations in B cell-derived human malignancy.
Advances in cancer research - 1 Jan 2001
Stevenson F K, Sahota S S, Ottensmeier C H, Zhu D, Forconi F, Hamblin T J
Abstract excerpt
The classification of B cell tumors has relevance for refining and improving clinical strategies. However, consensus has been difficult to establish, and although a scheme is now available, objective criteria are desirable. Genetic technology will underpin and extend current knowledge, and it is certain to reveal further subdivisions of current tumor categories. The Ig variable region genes of B cell tumors...
Topics
- B-Lymphocytes
- Chromosomes
- Humans
- Immunoglobulin Variable Region
- Leukemia
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphoma, Follicular
- Models, Biological
- Models, Genetic
- Multiple Myeloma
- Mutation
- Prognosis
- Recombination, Genetic
- Time Factors
- Translocation, Genetic
