Conserved patterns of somatic mutation and secondary VH gene rearrangement create aberrant Ig-encoding genes in Epstein-Barr virus-transformed and normal human B lymphocytes.

doi:10.1093/intimm/4.2.197

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Article

Conserved patterns of somatic mutation and secondary VH gene rearrangement create aberrant Ig-encoding genes in Epstein-Barr virus-transformed and normal human B lymphocytes.

International immunology - 1 Feb 1992

Brokaw J L, Wetzel S M, Pollok B A

Abstract excerpt

Expression of N-terminal-truncated Ig heavy chains without normal light chain expression has been shown to occur in human B cell tumor lines, and to be due to diverse types of structural alteration within the expressed Ig heavy and light chain genes. Due to the tumor cell origin of these lines, g...

Topics

Amino Acid Sequence
B-Lymphocytes
Base Sequence
Blotting, Northern
Blotting, Southern
Cell Transformation, Viral
DNA
Gene Rearrangement
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Light Chains

Immunoglobulin Variable Region

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Polymerase Chain Reaction

RNA

Source

Open in PubMed

Identifiers

PMID: 1377945
DOI: 10.1093/intimm/4.2.197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1377945-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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