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Article

Analysis of the kappa light chain variable region in multiple myeloma.

British journal of haematology - 1 Aug 1996

Kosmas C, Viniou N A, Stamatopoulos K, Courtenay-Luck N S, Papadaki T, Kollia P, Paterakis G, Anagnostou D, Yataganas X, Loukopoulos D

Abstract excerpt

The study of immunoglobulin heavy chain gene rearrangements in multiple myeloma has revealed extensive divergence from the germline sequences, but no intraclonal diversity with disease evolution. Our study investigated the state of the rearranged kappa light chain variable region (V kappa) gene s...

Topics

Amino Acid Sequence
Base Sequence
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Humans
Immunohistochemistry
Molecular Sequence Data
Multiple Myeloma
Mutation
Polymerase Chain Reaction
Sequence Analysis

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Source

Identifiers

PMID: 8759891
DOI: 10.1046/j.1365-2141.1996.d01-1815.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8759891-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Analysis of the kappa light chain variable region in multiple myeloma.PMID 8759891Read ↗

Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma.Semantic proximity Read ↗

Immunoglobulin genes in multiple myeloma: expressed and non-expressed repertoires, heavy and light chain pairings and somatic mutation patterns in a series of 101 cases.Semantic proximity Read ↗

Variable kappa gene rearrangement in lymphoproliferative disorders: an analysis of V kappa gene usage, VJ joining and somatic mutation.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma.Semantic proximity Read ↗

Myeloma VL and VH Gene Sequences Reveal a Complementary Imprint of Antigen Selection in Tumor CellsSemantic proximity Read ↗

Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.Semantic proximity Read ↗

V kappa gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the V kappa locus and do not show somatic mutation.Semantic proximity Read ↗

Insights into the regulation of immunoglobulin light chain gene rearrangements via analysis of the kappa light chain locus in lambda myeloma.Semantic proximity Read ↗

Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation.Semantic proximity Read ↗

Kappa deleting element as an alternative molecular target for minimal residual disease assessment by real-time quantitative PCR in patients with multiple myeloma.Semantic proximity Read ↗

Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity.Semantic proximity Read ↗

Low frequencies of somatic mutation in two expressed V kappa genes: unequal distribution of mutation in 5' and 3' flanking regions.Semantic proximity Read ↗

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