Distribution and nucleotide biases of the somatic hypermutations in the functional kappa light chain gene of a human follicular lymphoma line.

doi:10.1046/j.1365-3083.1996.d01-27.x

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Article

Distribution and nucleotide biases of the somatic hypermutations in the functional kappa light chain gene of a human follicular lymphoma line.

Scandinavian journal of immunology - 1 Feb 1996

Wu H, Kaartinen M

Abstract excerpt

The immunoglobulin kappa chain gene of human lymphoma cell line HF-1.3.4 was partially sequenced from the 3' end of the leader exon 2.0 kb downstream. The sequenced stretch of DNA included 1.5 kb of the non-coding JK region 3' to the JK2 element of the mature gene. Among the known VK germline gen...

Topics

Amino Acid Sequence
Base Sequence
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Humans
Immunoglobulin kappa-Chains
Lymphoma, Follicular
Molecular Sequence Data
Mutation
Tumor Cells, Cultured

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