Article
Distribution and nucleotide biases of the somatic hypermutations in the functional kappa light chain gene of a human follicular lymphoma line.
Scandinavian journal of immunology - 1 Feb 1996
Wu H, Kaartinen M
Abstract excerpt
The immunoglobulin kappa chain gene of human lymphoma cell line HF-1.3.4 was partially sequenced from the 3' end of the leader exon 2.0 kb downstream. The sequenced stretch of DNA included 1.5 kb of the non-coding JK region 3' to the JK2 element of the mature gene. Among the known VK germline genes the closet relative was KV328, which was 91% homologous to HF-1.3.4. In the 1.5 kb JK region homology with JK allele...
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