Article
Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma.
Blood - 15 Jun 1994
Wagner S D, Martinelli V, Luzzatto L
Abstract excerpt
To compare V kappa gene usage and the amount of somatic mutation in rearranged Ig genes from patients with lymphoproliferative disorders, we have polymerase chain reaction-amplified and sequenced a total of 26 V kappa genes from a total of 55 cases. Six sequences were obtained both from six cases of prolymphocytic leukemia (PLL) and from nine cases of hairy cell leukemia (HCL). Seven sequences were obtained both...
Topics
- Amino Acid Sequence
- Base Sequence
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Leukemia, Hairy Cell
- Leukemia, Prolymphocytic
- Molecular Sequence Data
- Multiple Myeloma