Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutations and intraclonal variations in the rearranged Vkappa genes of B-non-Hodgkin's lymphoma cell lines.

European journal of haematology - 1 Sept 1999

Gabay C, Ben-Bassat H, Schlesinger M, Laskov R

Abstract excerpt

Three established Burkitt's lymphoma (BL) cell lines (Daudi, Raji and DG-75) and three B-non-Hodgkin's lymphoma (B-NHL) of other types (Pfeiffer, Farage and Toledo) were analyzed with respect to the presence of somatic point mutations in their rearranged immunoglobulin Vkappa genes. Two of the Vkappa sequences of BL and two of those of the B-NHL were heavily mutated (up to 11%), when compared with their closest...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to DNA, Neoplasm
Share to Gene Rearrangement

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin kappa-Chains

Share to Immunoglobulin Variable Region

Share to Immunophenotyping

Share to Lymphoma, B-Cell

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 10485273
DOI: 10.1111/j.1600-0609.1999.tb01766.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations and intraclonal variations in the rearranged Vkappa genes of B-non-Hodgkin's lymphoma cell lines.PMID 10485273Read ↗

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.Semantic proximity Read ↗

IgV(H) and bcl6 somatic mutation analysis reveals the heterogeneity of cutaneous B-cell lymphoma, and indicates the presence of undisclosed local antigens.Semantic proximity Read ↗

Somatic mutations in the Ig variable region genes and expression of novel Cmu-germline transcripts in a B-lymphoma cell line ("Farage") not producing Ig polypeptide chains.Semantic proximity Read ↗

Clonal evolution in a primary cutaneous follicle center B cell lymphoma revealed by single cell analysis in sequential biopsies.Semantic proximity Read ↗

Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin VHDJH Gene DiversificationSemantic proximity Read ↗

Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes.Semantic proximity Read ↗

Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.Semantic proximity Read ↗

Variable kappa gene rearrangement in lymphoproliferative disorders: an analysis of V kappa gene usage, VJ joining and somatic mutation.Semantic proximity Read ↗

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.Semantic proximity Read ↗

Amino acid insertions and deletions contribute to diversify the human Ig repertoire.Semantic proximity Read ↗

Distribution and nucleotide biases of the somatic hypermutations in the functional kappa light chain gene of a human follicular lymphoma line.Semantic proximity Read ↗

Preferential targeting of somatic hypermutation to hotspot motifs and hypermutable sites and generation of mutational clusters in the IgVH alleles of a rheumatoid factor producing lymphoblastoid cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.