Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

V(H) gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia.

Haematologica - 1 Nov 2003

Duke Veronique M, Gandini Domenica, Sherrington Paul D, Lin Ke, Heelan Bridget, Amlot Peter, Mehta Atul B, Hoffbrand A Victor, Foroni Letizia

Abstract excerpt

BACKGROUND AND OBJECTIVES: Given the prognostic relevance that the identification of mutated and germline subgroups of chronic lymphocytic leukemia (CLL) has recently acquired we set out to analyze in depth individual VH gene usage rearrangements in patients with mutated and germline CLL. DESIGN AND METHODS: Using sequence analysis of FR1/JH polymerase chain reaction products, the VH immunoglobulin gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complementarity Determining Regions
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Joining Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Neoplastic Stem Cells

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 14607755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

V(H) gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia.PMID 14607755Read ↗

Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.Semantic proximity Read ↗

Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells.Semantic proximity Read ↗

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular featuresSemantic proximity Read ↗

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.Semantic proximity Read ↗

Determining mutational status of immunoglobulin v genes in chronic lymphocytic leukemia: a useful prognostic indicator.Semantic proximity Read ↗

VH gene usage by family members affected with chronic lymphocytic leukaemia.Semantic proximity Read ↗

[Overrepresentation of specific gene segments of expressed immunoglobulin heavy chain variable region among unmutated and mutated patients with chronic lymphocytic leukemia].Semantic proximity Read ↗

The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process.Semantic proximity Read ↗

Immunoglobulin gene segment usage, location and immunogenicity in mutated and unmutated chronic lymphocytic leukaemiaSemantic proximity Read ↗

Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL.Semantic proximity Read ↗

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.