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Article

V kappa gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the V kappa locus and do not show somatic mutation.

European journal of immunology - 1 Feb 1993

Wagner S D, Luzzatto L

Abstract excerpt

The structure of the human V kappa locus has been thoroughly investigated, but how the germ-line V kappa gene segment repertoire is actually sampled in kappa chain gene rearrangements is not known. In order to begin to answer this question we have polymerase chain reaction (PCR) amplified the rea...

Topics

Aged
Amino Acid Sequence
Base Sequence
Blotting, Southern
Chromosome Mapping
Female
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Humans
Hybrid Cells
Immunoglobulin kappa-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Lymphocytic, Chronic, B-Cell

Male

Middle Aged

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 8436174
DOI: 10.1002/eji.1830230214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8436174-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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