Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

V kappa gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the V kappa locus and do not show somatic mutation.

European journal of immunology - 1 Feb 1993

Wagner S D, Luzzatto L

Abstract excerpt

The structure of the human V kappa locus has been thoroughly investigated, but how the germ-line V kappa gene segment repertoire is actually sampled in kappa chain gene rearrangements is not known. In order to begin to answer this question we have polymerase chain reaction (PCR) amplified the rearranged V kappa genes from 26 kappa-expressing cases of chronic lymphocytic leukemia (CLL), followed by cloning and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Southern

Share to Chromosome Mapping

Share to Genes, Immunoglobulin

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8436174
DOI: 10.1002/eji.1830230214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

V kappa gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the V kappa locus and do not show somatic mutation.PMID 8436174Read ↗

Variable kappa gene rearrangement in lymphoproliferative disorders: an analysis of V kappa gene usage, VJ joining and somatic mutation.Semantic proximity Read ↗

Most kappa immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes.Semantic proximity Read ↗

Diversity of immunoglobulin kappa light chain gene rearrangements and evidence for somatic mutation in V kappa IV family gene segments in X-linked agammaglobulinemia.Semantic proximity Read ↗

Sequence analysis of light chain genes from human intestinal plasma cells demonstrates that lambda genes are almost all in-frame and highly mutated and most kappa genes are highly mutated when in-frame and minimally mutated when out-of-frame.Semantic proximity Read ↗

A mutated promoter of a human Ig V lambda gene segment is associated with reduced germ-line transcription and a low frequency of rearrangement.Semantic proximity Read ↗

V(H) gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

The creation of diversity in the human immunoglobulin V(lambda) repertoire.Semantic proximity Read ↗

The normally expressed kappa immunoglobulin light chain gene repertoire and somatic mutations studied by single-sided specific polymerase chain reaction (PCR); frequent occurrence of features often assigned to autoimmunity.Semantic proximity Read ↗

The structural repertoire of the human V kappa domain.Semantic proximity Read ↗

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.Semantic proximity Read ↗

Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.Semantic proximity Read ↗

Immunoglobulin gene segment usage, location and immunogenicity in mutated and unmutated chronic lymphocytic leukaemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.