Article
Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2011
Ghiotto Fabio, Marcatili Paolo, Tenca Claudya, Calevo Maria Grazia, Yan Xiao-Jie, Albesiano Emilia, Bagnara Davide, Colombo Monica, Cutrona Giovanna, Chu Charles C, Morabito Fortunato, Bruno Silvia, Ferrarini Manlio, Tramontano Anna, Fais Franco, Chiorazzi Nicholas
Abstract excerpt
B-cell chronic lymphocytic leukemia (CLL) patients display leukemic clones bearing either germline or somatically mutated immunoglobulin heavy variable (IGHV ) genes. Most information on CLL immunoglobulins (Igs), such as the definition of stereotyped B-cell receptors (BCRs), was derived from germline unmutated Igs. In particular, detailed studies on the distribution and nature of mutations in paired heavy- and...
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