Article
Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
Carcinogenesis - 1 Dec 1999
Wali R K, Skarosi S, Hart J, Zhang Y, Dolan M E, Moschel R C, Nguyen L, Mustafi R, Brasitus T A, Bissonnette M
Abstract excerpt
Azoxymethane (AOM) causes O(6)-methylguanine adduct formation which leads to G-->A transitions. Their repair is carried out by O(6)-methylguanine-DNA methyltransferase (MGMT). To evaluate the importance of this repair event in AOM-induced carcinogenesis, we examined the effect of O(6)-benzylguanine (BG), a potent inhibitor of MGMT, on colonic tumor development. Rats were treated weekly for 2 weeks at 0 and 24 h...
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