Article
Chemoprevention of intestinal adenomas in the ApcMin mouse by piroxicam: kinetics, strain effects and resistance to chemosuppression.
Carcinogenesis - 1 Jan 1999
Ritland S R, Gendler S J
Abstract excerpt
Previous cancer chemoprevention studies have demonstrated that NSAIDs can be effective in suppressing the development of intestinal tumors. To further explore this issue, we performed cross-over chemoprevention studies using the drug piroxicam in the ApcMin mouse to evaluate the kinetics of NSAID...
Topics
- Adenoma
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Anticarcinogenic Agents
- Apoptosis
- Colonic Neoplasms
- Crosses, Genetic
- Cyclooxygenase Inhibitors
- Diet
- Dose-Response Relationship, Drug
- Drug Resistance
- Duodenal Neoplasms
- Female
- Genes, APC
- Genetic Predisposition to Disease
- Intestinal Diseases
- Intestinal Neoplasms
- Loss of Heterozygosity