Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.

doi:10.1002/humu.1380030307

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Article

Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.

Human mutation - 1 Jan 1994

Gessler M, König A, Arden K, Grundy P, Orkin S, Sallan S, Peters C, Ruyle S, Mandell J, Li F

Abstract excerpt

Homozygous deletions in Wilms' tumor DNA have been a key step in the identification and isolation of the WT1 gene. Several additional loci are also postulated to contribute to Wilms' tumor formation. To assess the frequency of WT1 alterations we have analyzed the WT1 locus in a panel of 77 Wilms'...

Topics

Amino Acid Sequence
Base Sequence
Child, Preschool
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 11
DNA Primers
DNA, Neoplasm
Exons
Female
Gene Deletion
Genes, Wilms Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

Infant

Introns

Kidney

Kidney Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8019557
DOI: 10.1002/humu.1380030307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8019557-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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