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Genome-wide loss of heterozygosity analysis of WT1-wild-type and WT1-mutant Wilms tumors.

Genes, chromosomes & cancer - 1 Jun 2005

Ruteshouser E Cristy, Hendrickson Brett W, Colella Stefano, Krahe Ralf, Pinto Lancelot, Huff Vicki

Abstract excerpt

Wilms tumor (WT) is genetically heterogeneous, and the one known WT gene, WT1 at 11p13, is altered in only a subset of WTs. Previous loss of heterozygosity (LOH) analyses have revealed the existence of additional putative WT genes at 11p15, 16q, and 1p, but these analyses examined only one or a handful of chromosomes or looked at LOH at only a few markers per chromosome. We conducted a genome-wide scan for LOH in...

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PMID: 15761866
DOI: 10.1002/gcc.20169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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