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Article

Molecular genetics of Wilms tumor.

Hematology/oncology clinics of North America - 1 Dec 1995

Grundy P, Coppes M J, Haber D

Abstract excerpt

The study of Wilms tumor-predisposing congenital syndromes has led to the identification of one tumor-suppressor gene, WT1, and to the localization of WT2. Molecular genetic analyses of these and sporadic Wilms tumors have clarified the role of WT1 in Wilms tumor with aniridia, genitourinary malformations, and mental retardation (WAGR)-syndrome patients, but much remains unclear in the case of WT2 and the...

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PMID: 8591961

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