Article
<i>WTX</i> inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact
16 Sept 2009
Abstract excerpt
Wilms tumor (WT) is one of the most common solid tumors in childhood. Mutations in WT1 and CTNNB1 are well established as causal alterations in about 10-15% of cases. Recently, WTX (WT gene on the X-chromosome), a gene implicated in WNT signaling, has been identified as a third WT gene. We determined the mutation status of WTX, CTNNB1, and WT1 in a large set of 429 tumors. Genomic WTX alterations were identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.