Article
Constitutional and somatic mutations in the WT1 gene in Wilms' tumor patients.
International journal of cancer - 15 Nov 1995
Nordenskjöld A, Friedman E, Sandstedt B, Söderhäll S, Anvret M
Abstract excerpt
Wilms' tumor development, like most tumors, involves multiple genetic alterations affecting diverse genes. Only one of these has thus far been identified, the Wilms' tumor 1 (WT1) gene on 11p13, which functions as a tumor suppressor gene. We assessed the involvement of the WT1 gene constitutional...
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- Child
- Child, Preschool
- DNA, Neoplasm
- DNA, Satellite
- DNA-Binding Proteins
- Electrophoresis
- Exons
- Female
- Gene Deletion
- Gene Rearrangement
- Genes, Wilms Tumor
- Heterozygote
- Humans
- Infant
- Male