Article
Fine structure analysis of the WT1 gene in sporadic Wilms tumors.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 1994
Varanasi R, Bardeesy N, Ghahremani M, Petruzzi M J, Nowak N, Adam M A, Grundy P, Shows T B, Pelletier J
Abstract excerpt
Molecular genetic studies indicate that the etiology of Wilms tumor (WT) is complex, involving at least three loci. Germ-line mutations in the tumor suppressor gene, WT1, have been documented in children with WTs and urogenital developmental anomalies. Sporadic tumors constitute the majority (> 90%) of WT cases and previous molecular analyses of the WT1 gene have focused only on the DNA-binding domain. Using the...
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